Senolytic Activator- Bio-Quercetin/Theaflavin/Apigenin/Bio-Fisetin Formula -36 Vcaps

About Life Extension Senolytic Activator:

Life Extension Senolytic Activator combines black tea theaflavins, the plant-derived
flavonoid apigenin, and ultra-absorbable forms of the bio-flavonoids quercetin and fisetin to help manage senescent cell burden and promote systemic rejuvenation.

Senolytic Activator Benefits:
  • Helps the body manage senescent cells
  • Promotes youthful, healthy cellular function
  • Supports systemic rejuvenation
  • Made with black tea theaflavins, apigenin, plus highly absorbable quercetin and fisetin
  • Convenient once-a-week dosing

Product Details

Cellular senescence is a natural part of the aging process in which cells no longer
function optimally. Senescent cells can accumulate over time, affecting the day-to-day
function of the healthy cells around them.

Senolytic compounds selectively target senescent cells.1 New research indicates that
black tea theaflavins and quercetin target specific biological pathways, making it easier for the body to manage senescent cells.

Theaflavins reduce senescent cell burden

Theaflavins are compounds derived from Camellia sinensis (tea plant). These compounds have widespread health benefits, supporting healthy cell division and healthy inflammatory response.

New research indicates that theaflavins may be especially helpful for reducing senescent cell burden. In pre-clinical models, theaflavins helped powerfully inhibit the
accumulation of particular cell senescence biomarkers.

Quercetin promotes cellular health and more

Quercetin supports endothelial and cardiovascular health, promotes healthy immune function and more. The value of quercetin has been recognized for some time. But its potential to meaningfully impact whole body rejuvenation is just starting to be uncovered through its senolytic activity. The discovery that quercetin is a senolytic compound has drawn significant attention to this innovative approach to combat aging.

Better absorption than standard types of quercetin

Standard quercetin is hard to absorb. But this formulation features our new quercetin
phytosome, a phospholipid sphere that encases the quercetin, aiding in its absorption and making it up to 50 times more bioavailable.

Easy-to-absorb fisetin to boost longevity at the cellular level

Fisetin is terrific for whole-body health. It’s a powerful senolytic compound, meaning it
actively target senescent cells, the ones that no longer function optimally. Fisetin helps
encourage the body’s natural pathways for clearing senescent cells, which allows healthy cells to flourish.

Another important aspect of cellular longevity is sirtuin function. Sirtuin proteins keep
your cells performing at their best—but sirtuin activity declines with age.10 Fisetin has
been shown in preclinical studies to encourage youthful, healthy sirtuin function.11-15

But during digestion, much of fisetin is rapidly converted into other compounds by a
process called conjugation. That’s why we protected fisetin by combining it with
galactomannans, a type of fiber derived from fenugreek seed. Doing so makes it up to
25 times more readily available than standard fisetin. That means it circulates in your
system longer and your body has more time to access fisetin’s many health benefits.


Life Extension has identified apigenin, a natural flavonoid, as a powerful addition to our Senolytic Activator® formula. Quercetin and theaflavins from black tea target senescent cells, but not all of them.

The remaining senescent cells create compounds known collectively as Senescence Associated Secretory Phenotype, or SASP. Apigenin helps inhibit remaining senescent cells from making SASP to support cellular and tissue health—a critical aspect of healthy aging.

Convenient, once-weekly formula

For those who aren’t keen on adding another supplement to their regimen, here’s good news: Senolytic research indicates that intermittent dosing in pre-clinical studies is effective at supporting healthspan. So, Senolytic Activator® instructions call for taking just three vegetarian capsules, once a week.
Manage senescent cells, promote healthy cellular function and support overall longevity with Senolytic Activator®

Supplement Facts:
Serving Size 3 vegetarian capsules

Servings Per Container 12

Amount Per Serving:

Proprietary Blend                                                                                              312 mg
  Providing 18% fisetin (56 mg) [from wax tree extract (stem)], 35% galactomannans     (109 mg) [from fenugreek (seed)]
Theaflavins [from decaffeinated black tea extract (leaf)]                                  275 mg

Bio-Quercetin phytosome (providing 25 mg quercetin [from Japanese sophora concentrate (flower bud)], phosphatidylcholine complex [from sunflower])    74 mg
Apigenin                                                                                                            50 mg

Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, silica,
vegetable stearate.


Dosage and Use
Take three (3) capsules once weekly, or as recommended by a healthcare practitioner.

These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.